Transcriptional profiling from young, old, healthy, or injured rat iliac arteries.
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Lina Shehadeh
PROVIDER: E-GEOD-29255 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging.
Shehadeh Lina A LA Webster Keith A KA Hare Joshua M JM Vazquez-Padron Roberto I RI
PloS one 20111007 10
<h4>Background</h4>Aging-associated changes in the cardiovascular system increase the risk for disease development and lead to profound alterations in vascular reactivity and stiffness. Elucidating the molecular response of arteries to injury and age will help understand the exaggerated remodeling of aging vessels.<h4>Methodology/principal findings</h4>We studied the gene expression profile in a model of mechanical vascular injury in the iliac artery of aging (22 months old) and young rats (4 mo ...[more]
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