Human Hematopoietic and Leukemic Stem Cell Gene Expression Profiles
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kolja Eppert
PROVIDER: E-GEOD-30377 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Stem cell gene expression programs influence clinical outcome in human leukemia.
Eppert Kolja K Takenaka Katsuto K Lechman Eric R ER Waldron Levi L Nilsson Björn B van Galen Peter P Metzeler Klaus H KH Poeppl Armando A Ling Vicki V Beyene Joseph J Canty Angelo J AJ Danska Jayne S JS Bohlander Stefan K SK Buske Christian C Minden Mark D MD Golub Todd R TR Jurisica Igor I Ebert Benjamin L BL Dick John E JE
Nature medicine 20110828 9
Xenograft studies indicate that some solid tumors and leukemias are organized as cellular hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its relevance in humans remains uncertain. Here we show that acute myeloid leukemia (AML) follows a CSC model on the basis of sorting multiple populations from each of 16 primary human AML samples and identifying which contain leukemia stem cells (LSCs) using a sensitive xenograft assay. Analysis of gene expression from ...[more]
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