Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shalini Oberdoerffer
PROVIDER: E-GEOD-31486 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shukla Sanjeev S Kavak Ersen E Gregory Melissa M Imashimizu Masahiko M Shutinoski Bojan B Kashlev Mikhail M Oberdoerffer Philipp P Sandberg Rickard R Oberdoerffer Shalini S
Nature 20111101 7371
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co-transcriptionally, raising the possibility that DNA structure may directly influence alternative splicing. Supporting such an association, recent reports have identified distinct histone methylation patterns, elevated nucleosome occupancy and enriched DNA methylation at exons relative to introns. Moreover, the rate of t ...[more]