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FOXM1 Orchestrates a Global Methylation Signature that Mimics the Cancer Epigenome

ABSTRACT: Aberrant upregulation of a single oncogene FOXM1 in primary normal human oral epithelial cells orchestrated a cancer-like methylome landscape This study have identified a unique FOXM1-induced epigenetic signature which may have potentials as biomarkers for early oral cancer screening, diagnostic and/or therapeutic interventions Comparisons of primary human normal oral keratinocytes transduced with either EGFP (control) or FOXM1B and a head and neck squamous cell carcinoma cell line SCC15

ORGANISM(S): Homo sapiens

SUBMITTER: Dr. Muy-Teck Teh

PROVIDER: E-GEOD-31767 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.

Teh Muy-Teck MT Gemenetzidis Emilios E Patel Deeviyaben D Tariq Rameez R Nadir Ayesha A Bahta Adiam W AW Waseem Ahmad A Hutchison Iain L IL

PloS one 20120326 3

The oncogene FOXM1 has been implicated in all major types of human cancer. We recently showed that aberrant FOXM1 expression causes stem cell compartment expansion resulting in the initiation of hyperplasia. We have previously shown that FOXM1 regulates HELLS, a SNF2/helicase involved in DNA methylation, implicating FOXM1 in epigenetic regulation. Here, we have demonstrated using primary normal human oral keratinocytes (NOK) that upregulation of FOXM1 suppressed the tumour suppressor gene p16(IN ...[more]

PMID: 22461910

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