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DNA methylation epigenotype expanding to non-polycomb target genes, induced by Epstein-Barr virus infection in human gastric cancer

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE31787: Aberrant DNA methylation epigenotype expanding to non-polycomb target genes, induced by Epstein-Barr virus infection in human gastric cancer [Affymetrix Expression] GSE31788: Aberrant DNA methylation epigenotype expanding to non-polycomb target genes, induced by Epstein-Barr virus infection in human gastric cancer [Illumina Methylation] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Atsushi Kaneda

PROVIDER: E-GEOD-31789 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes.

Matsusaka Keisuke K Kaneda Atsushi A Nagae Genta G Ushiku Tetsuo T Kikuchi Yasuko Y Hino Rumi R Uozaki Hiroshi H Seto Yasuyuki Y Takada Kenzo K Aburatani Hiroyuki H Fukayama Masashi M

Cancer research 20111011 23

Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies human gastric carcinogenesis, though the contribution of EBV to such somatic methylation changes has not been fully clarified. We analyzed promoter methylation in gastric cancer cases with Illumina's Infinium BeadArray and used hierarchical clustering analysis to classify gastric ca ...[more]

PMID: 21990320

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