Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Ezh2-null erythrocyte/megakaryocyte progenitor (MEP)


ABSTRACT: The polycomb group (PcG) proteins function in gene silencing through histone modifications. They form chromatin-associated multiprotein complexes, termed polycomb repressive complex (PRC) 1 and PRC2. These two complexes work in a coordinated manner in the maintenance of cellular memories through transcriptional repression of target genes. EZH2 is a catalytic component of PRC2 and trimethylates histone H3 at lysine 27 to transcriptionally repress the target genes. PcG proteins have been characterized as general regulators of stem cells, but recent works also unveiled their critical roles in cancer. Wild type and Ezh2 null MEP from fetal liver and adult bone marrow

ORGANISM(S): Mus musculus

SUBMITTER: ATSUSHI IWAMA 

PROVIDER: E-GEOD-32929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

Mochizuki-Kashio Makiko M   Mishima Yuta Y   Miyagi Satoru S   Negishi Masamitsu M   Saraya Atsunori A   Konuma Takaaki T   Shinga Jun J   Koseki Haruhiko H   Iwama Atsushi A  

Blood 20111031 25


Polycomb-group (PcG) proteins are essential regulators of hematopoietic stem cells (HSCs). In contrast to Bmi1, a component of Polycomb repressive complex 1 (PRC1), the role of PRC2 and its components in hematopoiesis remains elusive. Here we show that Ezh2, a core component of PRC2, is essential for fetal, but not adult, HSCs. Ezh2-deficient embryos died of anemia because of insufficient expansion of HSCs/progenitor cells and defective erythropoiesis in fetal liver. Deletion of Ezh2 in adult BM  ...[more]

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