Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: ATSUSHI IWAMA
PROVIDER: E-GEOD-32929 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20111031 25
Polycomb-group (PcG) proteins are essential regulators of hematopoietic stem cells (HSCs). In contrast to Bmi1, a component of Polycomb repressive complex 1 (PRC1), the role of PRC2 and its components in hematopoiesis remains elusive. Here we show that Ezh2, a core component of PRC2, is essential for fetal, but not adult, HSCs. Ezh2-deficient embryos died of anemia because of insufficient expansion of HSCs/progenitor cells and defective erythropoiesis in fetal liver. Deletion of Ezh2 in adult BM ...[more]