Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Todd Macfarlan
PROVIDER: E-GEOD-33920 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature 20120701 7405
Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all extraembryonic tissues. Here we identify a rare transient cell population within mouse ES and induced pluripotent stem (iPS) cell cultures that expresses high levels of transcripts found in two-cell (2C) embryos in which the blastomeres are totipotent. We genetically tagged these 2C-like ES cells and show that they lack t ...[more]