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RNA-Seq from wt oocytes

ABSTRACT: To determine gene expression in mouse ovulated oocytes 3 Replicates of litters of wild type ovulated oocytes

ORGANISM(S): Mus musculus

SUBMITTER: Todd Macfarlan

PROVIDER: E-GEOD-33922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Embryonic stem cell potency fluctuates with endogenous retrovirus activity.

Macfarlan Todd S TS Gifford Wesley D WD Driscoll Shawn S Lettieri Karen K Rowe Helen M HM Bonanomi Dario D Firth Amy A Singer Oded O Trono Didier D Pfaff Samuel L SL

Nature 20120701 7405

Embryonic stem (ES) cells are derived from blastocyst-stage embryos and are thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all extraembryonic tissues. Here we identify a rare transient cell population within mouse ES and induced pluripotent stem (iPS) cell cultures that expresses high levels of transcripts found in two-cell (2C) embryos in which the blastomeres are totipotent. We genetically tagged these 2C-like ES cells and show that they lack t ...[more]

PMID: 22722858

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2012-06-17 | E-GEOD-33923 | biostudies-arrayexpress

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A comparative epigenomics approach reveals REST as a mediator of Polycomb reprogramming during neuronal differentiation

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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