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Influence of intrauterine low protein diet on ductal morphogenesis of the rat mammary gland.

ABSTRACT: Following intrauterine low protein diet, the lumbar mammary gland of control and low protein rats were removed for further analysis via genarray on day 21 and day 28 postpartum. Virgin female Wistar rats came from Charles River. Throughout pregnancy the NP rats received 25g/d of Altromin C1000 containing 17.0% protein, while LP animals were fed 25g/d of Altromin C1003 containing 8.8% protein. At birth, litter size was reduced to 6 females in both groups, which were left to suckle for 21 days. During lactation (d1-d21) and after weaning (d21-d28) NP and LP animals were fed a standard chow and tap water ad libitum. At d21 and d28 3 dams were sacrificed under isofluran narcosis. The lumbar mammary gland (4th and 5th pair) were removed and cleared of visible lymph nodes before snap-freezing in liquid nitrogen.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Fabian Fahlbusch 

PROVIDER: E-GEOD-34136 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Detection of expressional changes induced by intrauterine growth restriction in the developing rat mammary gland via exploratory pathways analysis.

Beinder Lea L   Faehrmann Nina N   Wachtveitl Rainer R   Winterfeld Ilona I   Hartner Andrea A   Menendez-Castro Carlos C   Rauh Manfred M   Ruebner Matthias M   Huebner Hanna H   Noegel Stephanie C SC   Doerr Helmuth G HG   Rascher Wolfgang W   Fahlbusch Fabian B FB  

PloS one 20140623 6

<h4>Background</h4>Intrauterine growth restriction (IUGR) is thought to lead to fetal programming that in turn contributes to developmental changes of many organs postnatally. There is evidence that IUGR is a risk factor for the development of metabolic and cardiovascular disease later in life. A higher incidence of breast cancer was also observed after IUGR. This could be due to changes in mammary gland developmental pathways. We sought to characterise IUGR-induced alterations of the complex pa  ...[more]

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