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Aging Experiment

ABSTRACT: Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs Five tissues: Kidney, Liver, Lung, Spleen, Brain. Six timepoints: 13wks, 26 wks, 52wks, 78wks, 104wks, 130wks. One Genotype: C57Bl/6, 3 replicates

ORGANISM(S): Mus musculus

SUBMITTER: Paul Wackers

PROVIDER: E-GEOD-34378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.

Jonker Martijs J MJ Melis Joost Pm JP Kuiper Raoul V RV van der Hoeven Tessa V TV Wackers P F K PFK Robinson Joke J van der Horst Gijsbertus Tj GT Dollé Martijn Et ME Vijg Jan J Breit Timo M TM Hoeijmakers Jan Hj JH van Steeg Harry H

Aging cell 20130714 5

Aging and age-related pathology is a result of a still incompletely understood intricate web of molecular and cellular processes. We present a C57BL/6J female mice in vivo aging study of five organs (liver, kidney, spleen, lung, and brain), in which we compare genome-wide gene expression profiles during chronological aging with pathological changes throughout the entire murine life span (13, 26, 52, 78, 104, and 130 weeks). Relating gene expression changes to chronological aging revealed many di ...[more]

PMID: 23795901

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