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Transcription profiling of mouse P18, P24, P46, P104, and P46DR (dark reared) non-deprived vs. deprived visual cortex (GEO Super Series)

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE4263: P18 mouse non-deprived vs. deprived visual cortex; GSE4264: P24 mouse non-deprived vs. deprived visual cortex; GSE4265: P46 mouse non-deprived vs. deprived visual cortex; GSE4266: P104 mouse non-deprived vs. deprived visual cortex; GSE4267: P46DR (dark reared) mouse non-deprived vs. deprived visual cortex Experiment Overall Design: Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Marta Majdan

PROVIDER: E-GEOD-4269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of visual experience on activity-dependent gene regulation in cortex.

Majdan Marta M Shatz Carla J CJ

Nature neuroscience 20060402 5

There are critical periods in development when sensory experience directs the maturation of synapses and circuits within neocortex. We report that the critical period in mouse visual cortex has a specific molecular logic of gene regulation. Four days of visual deprivation regulated one set of genes during the critical period, and different sets before or after. Dark rearing perturbed the regulation of these age-specific gene sets. In addition, a 'common gene set', comprised of target genes belon ...[more]

PMID: 16582906

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