Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Weng Khong Lim
PROVIDER: E-GEOD-38865 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Diffner Eva E Beck Dominik D Gudgin Emma E Thoms Julie A I JA Knezevic Kathy K Pridans Clare C Foster Sam S Goode Debbie D Lim Weng Khong WK Boelen Lies L Metzeler Klaus H KH Micklem Gos G Bohlander Stefan K SK Buske Christian C Burnett Alan A Ottersbach Katrin K Vassiliou George S GS Olivier Jake J Wong Jason W H JW Göttgens Berthold B Huntly Brian J BJ Pimanda John E JE
Blood 20130117 12
Aberrant transcriptional programs in combination with abnormal proliferative signaling drive leukemic transformation. These programs operate in normal hematopoiesis where they are involved in hematopoietic stem cell (HSC) proliferation and maintenance. Ets Related Gene (ERG) is a component of normal and leukemic stem cell signatures and high ERG expression is a risk factor for poor prognosis in acute myeloid leukemia (AML). However, mechanisms that underlie ERG expression in AML and how its expr ...[more]