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Helicobacter pylori-mediated Epigenetic Dysregulation of FOXD3 Tumor-suppressive Cascade In Gastric Carcinogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Alfred Cheng

PROVIDER: E-GEOD-39600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis.

Cheng Alfred S L AS Li May S MS Kang Wei W Cheng Victoria Y VY Chou Jian-Liang JL Lau Suki S SS Go Minnie Y MY Lee Ching C CC Ling Thomas K TK Ng Enders K EK Yu Jun J Huang Tim H TH To Ka F KF Chan Michael W MW Sung Joseph J Y JJ Chan Francis K L FK

Gastroenterology 20121008 1

<h4>Background & aims</h4>Deregulation of forkhead box (Fox) proteins, an evolutionarily conserved family of transcriptional regulators, leads to tumorigenesis. Little is known about their regulation or functions in the pathogenesis of gastric cancer. Promoter hypermethylation occurs during Helicobacter pylori-induced gastritis. We investigated whether the deregulated genes contribute to gastric tumorigenesis.<h4>Methods</h4>We used integrative genome-wide scans to identify concomitant hypermeth ...[more]

PMID: 23058321

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