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Ficolin-1 is upregulated in leukocytes and glomeruli from microscopic polyangiitis patients

ABSTRACT: To search for new markers of active lesions that might help better understand the molecular basis of MPA and aid in its diagnosis, DNA microarray analysis was performed with peripheral blood mononuclear cells (PBMCs). A total of 12 sets of two color arrays were performed and each individual array included a target sample and a control sample.

ORGANISM(S): Homo sapiens

SUBMITTER: Daisuke Okuzaki

PROVIDER: E-GEOD-41744 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients.

Muso Eri E Okuzaki Daisuke D Kobayashi Shigeto S Iwasaki Yukako Y Sakurai Minami A MA Ito Akihiko A Nojima Hiroshi H

Autoimmunity 20130815 8

Microscopic polyangiitis (MPA) is a systemic autoimmune disease that often has a fatal outcome. Although delineating the molecular pathogenesis is essential for its remedy, an understanding of its molecular mechanism has remained elusive. To search for new markers of active lesions that might help better understand the molecular basis of MPA and aid in its diagnosis, we here performed DNA microarray analysis with peripheral blood mononuclear cells (PBMCs). Compared to normal control, several gen ...[more]

PMID: 23944633

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