Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

50 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse visual cortex from P46 mouse non-deprived vs. deprived

ABSTRACT: Wild-type (C57Bl6) mice underwent monocular enucleation at P42 and were sacrificed 4 days later at P46. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall Design: Gene expression in pooled samples from 4 non-deprived (ipsilateral to monocular enucleation) and 4 deprived (contralateral to monocular enucleation) visual hemispheres was compared.

ORGANISM(S): Mus musculus

SUBMITTER: Marta Majdan

PROVIDER: E-GEOD-4265 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Effects of visual experience on activity-dependent gene regulation in cortex.

Majdan Marta M Shatz Carla J CJ

Nature neuroscience 20060402 5

There are critical periods in development when sensory experience directs the maturation of synapses and circuits within neocortex. We report that the critical period in mouse visual cortex has a specific molecular logic of gene regulation. Four days of visual deprivation regulated one set of genes during the critical period, and different sets before or after. Dark rearing perturbed the regulation of these age-specific gene sets. In addition, a 'common gene set', comprised of target genes belon ...[more]

PMID: 16582906

Similar Datasets

Transcription profiling of mouseP46DR dark reared mouse non-deprived vs. deprived visual cortex

Project description:Wild-type (C57Bl6) mice were dark reared from birth to P42, then underwent monocular enucleation at P42. They were then placed in a normal light-dark environment for 4 days, after which they were sacrificed (at P46). Visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall Design: Gene expression in pooled samples from 2 non-deprived (ipsilateral to monocular enucleation) and 2 deprived (contralateral to monocular enucleation) visual hemispheres was compared. Note: two additional cross-animal comparisons were made.

2008-06-13 | E-GEOD-4267 | biostudies-arrayexpress

Transcription profiling of mouse P18, P24, P46, P104, and P46DR (dark reared) non-deprived vs. deprived visual cortex (GEO Super Series)

Project description:This SuperSeries is composed of the following subset Series:; GSE4263: P18 mouse non-deprived vs. deprived visual cortex; GSE4264: P24 mouse non-deprived vs. deprived visual cortex; GSE4265: P46 mouse non-deprived vs. deprived visual cortex; GSE4266: P104 mouse non-deprived vs. deprived visual cortex; GSE4267: P46DR (dark reared) mouse non-deprived vs. deprived visual cortex Experiment Overall Design: Refer to individual Series

2008-06-13 | E-GEOD-4269 | biostudies-arrayexpress

Transcription profiling of mouse P104 non-deprived vs. deprived visual cortex

Project description:Wild-type (C57Bl6) mice underwent monocular enucleation at P100 and were sacrificed 4 days later at P104. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall Design: Gene expression in pooled samples from 3 non-deprived (ipsilateral to monocular enucleation) and 3 deprived (contralateral to monocular enucleation) visual hemispheres was compared.

2008-06-13 | E-GEOD-4266 | biostudies-arrayexpress

Transcription profiling of mouse P24 animals non-deprived vs. deprived visual cortex

Project description:Wild-type (C57Bl6) mice underwent monocular enucleation at P20 and were sacrificed 4 days later at P24. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall Design: Gene expression in pooled samples from 4 non-deprived (ipsilateral to monocular enucleation) and 4 deprived (contralateral to monocular enucleation) visual hemispheres was compared.

2008-06-13 | E-GEOD-4264 | biostudies-arrayexpress

P46 mouse non-deprived vs. deprived visual cortex

Project description:Wild-type (C57Bl6) mice underwent monocular enucleation at P42 and were sacrificed 4 days later at P46. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Keywords: repeat

2006-02-24 | GSE4265 | GEO

Transcription profiling of mouse visual cortex from wild type animals sacrificed at P18 after mononuclear enucleation

Project description:Wild-type (C57Bl6) mice underwent monocular enucleation at P14 and were sacrificed 4 days later at P18. Bilateral (non-deprived and deprived) visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall Design: Gene expression in pooled samples from 5 non-deprived (ipsilateral to monocular enucleation) and 5 deprived (contralateral to monocular enucleation) visual hemispheres was compared.

2008-06-13 | E-GEOD-4263 | biostudies-arrayexpress

P46DR (dark reared) mouse non-deprived vs. deprived visual cortex

2006-02-24 | GSE4267 | GEO

P24 mouse non-deprived vs. deprived visual cortex

2006-02-24 | GSE4264 | GEO

P18 mouse non-deprived vs. deprived visual cortex

2006-02-24 | GSE4263 | GEO

P104 mouse non-deprived vs. deprived visual cortex

2006-02-24 | GSE4266 | GEO