Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouseP46DR dark reared mouse non-deprived vs. deprived visual cortex

ABSTRACT: Wild-type (C57Bl6) mice were dark reared from birth to P42, then underwent monocular enucleation at P42. They were then placed in a normal light-dark environment for 4 days, after which they were sacrificed (at P46). Visual cortex was dissected from 1-mm thick coronal sections, and total RNA was extracted from the tissue lysate using Trizol (Gibco-BRL). Experiment Overall Design: Gene expression in pooled samples from 2 non-deprived (ipsilateral to monocular enucleation) and 2 deprived (contralateral to monocular enucleation) visual hemispheres was compared. Note: two additional cross-animal comparisons were made.

ORGANISM(S): Mus musculus

SUBMITTER: Marta Majdan 

PROVIDER: E-GEOD-4267 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Effects of visual experience on activity-dependent gene regulation in cortex.

Majdan Marta M   Shatz Carla J CJ  

Nature neuroscience 20060402 5

There are critical periods in development when sensory experience directs the maturation of synapses and circuits within neocortex. We report that the critical period in mouse visual cortex has a specific molecular logic of gene regulation. Four days of visual deprivation regulated one set of genes during the critical period, and different sets before or after. Dark rearing perturbed the regulation of these age-specific gene sets. In addition, a 'common gene set', comprised of target genes belon  ...[more]

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