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Unknown,Transcriptomics,Genomics,Proteomics

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Analyses of lung early responses to RSV in the neonatal environment reveal key roles for DC and type I IFN in controlling immunopathologic imprinting.

ABSTRACT: The gene expression profile of neonatal versus adult lung, 2 days after an RSV or mock infection was analyzed using whole mouse genome agilent microarrays. Total lung RNA were extracted, labeled with Cy3 and hybridized on Agilent G4122F slides. We used 4 biological replicates per condition.

ORGANISM(S): Mus musculus

SUBMITTER: Aude Remot

PROVIDER: E-GEOD-42759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Flt3 ligand improves the innate response to respiratory syncytial virus and limits lung disease upon RSV reexposure in neonate mice.

Remot Aude A Descamps Delphyne D Jouneau Luc L Laubreton Daphné D Dubuquoy Catherine C Bouet Stephan S Lecardonnel Jérôme J Rebours Emmanuelle E Petit-Camurdan Agnès A Riffault Sabine S

European journal of immunology 20160122 4

Respiratory syncytial virus (RSV) causes severe bronchiolitis in infants worldwide. The immunological factors responsible for RSV susceptibility in infants are poorly understood. Here, we used the BALB/c mouse model of neonatal RSV infection to study the mechanisms leading to severe disease upon reexposure to the virus when adults. Two major deficiencies in neonatal lung innate responses were found: a poor DCs mobilization, and a weak engagement of the IFNI pathway. The administration of Flt3 li ...[more]

PMID: 26681580

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