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MicroRNA sequence and expression analysis of rat liver tissue exposed to aflatoxin B1 by deep sequencing

ABSTRACT: We report the application of illumina deep sequencing technology for high-throughput profiling of microRNA in aflatoxin B1 treated rat liver tissue, as well as normal liver tissue. miRNAs of miR-17-92 cluster, thought to be tumor activating miRNAs, were down-regulated. miR-34a, considered to be a tumor suppressor, was up-regulated.Novel miRNAs and miRNA base alteration caused by SNP or editing were predicted and summarized. Examination of 2 microRNA profiles in 2 liver tissues under different treatments.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Weiqiang Yang

PROVIDER: E-GEOD-44826 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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