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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse brain regions (bed nucleus of the stria terminalis, hippocampus, hypothalamus, periaqueductal gray, and pituitary gland) in six mouse strains (129S6/SvEvTac, A/J, C57BL/6J, C3H/HeJ, DBA/2J, and FVB/NJ)

ABSTRACT: Gene expression patterns were determined from five brain regions (bed nucleus of the stria terminalis, hippocampus, hypothalamus, periaqueductal gray, and pituitary gland) in six mouse strains (129S6/SvEvTac, A/J, C57BL/6J, C3H/HeJ, DBA/2J, and FVB/NJ). At least two replicate samples per brain region/strain were analyzed using Affymetrix Mouse Genome 430 2.0 arrays. Experiment Overall Design: six mouse strains and five brain regions were analyzed

ORGANISM(S): Mus musculus

SUBMITTER: Carrolee Barlow

PROVIDER: E-GEOD-4734 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies.

Hovatta Iiris I Zapala Matthew A MA Broide Ron S RS Schadt Eric E EE Libiger Ondrej O Schork Nicholas J NJ Lockhart David J DJ Barlow Carrolee C

Genome biology 20070101 2

<h4>Background</h4>Expression quantitative trait locus (eQTL) mapping is used to find loci that are responsible for the transcriptional activity of a particular gene. In recent eQTL studies, expression profiles were derived from either homogenized whole brain or collections of large brain regions. However, the brain is a very heterogeneous organ, and expression profiles of different brain regions vary significantly. Because of the importance and potential power of eQTL studies in identifying reg ...[more]

PMID: 17324278

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