Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Carme Camps
PROVIDER: E-GEOD-47534 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Camps Carme C Saini Harpreet K HK Mole David R DR Choudhry Hani H Reczko Martin M Guerra-Assunção José Afonso JA Tian Ya-Min YM Buffa Francesca M FM Harris Adrian L AL Hatzigeorgiou Artemis G AG Enright Anton J AJ Ragoussis Jiannis J
Molecular cancer 20140211
<h4>Background</h4>In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide. Our aim is to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression.<h4 ...[more]