Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Integrated analysis of microRNA and mRNA expression and association with HIF binding in MCF-7 cells under hypoxia


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Carme Camps 

PROVIDER: E-GEOD-47534 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia.

Camps Carme C   Saini Harpreet K HK   Mole David R DR   Choudhry Hani H   Reczko Martin M   Guerra-Assunção José Afonso JA   Tian Ya-Min YM   Buffa Francesca M FM   Harris Adrian L AL   Hatzigeorgiou Artemis G AG   Enright Anton J AJ   Ragoussis Jiannis J  

Molecular cancer 20140211


<h4>Background</h4>In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide. Our aim is to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression.<h4  ...[more]

Similar Datasets

2014-02-13 | E-GEOD-47532 | biostudies-arrayexpress
2014-02-13 | E-GEOD-47602 | biostudies-arrayexpress
2013-02-11 | E-GEOD-39994 | biostudies-arrayexpress
2012-01-01 | E-GEOD-33986 | biostudies-arrayexpress
2010-09-12 | E-GEOD-22024 | biostudies-arrayexpress
2014-12-05 | E-GEOD-63341 | biostudies-arrayexpress
2010-02-01 | E-GEOD-18542 | biostudies-arrayexpress
2012-07-09 | E-GEOD-35754 | biostudies-arrayexpress
2012-12-25 | E-GEOD-39636 | biostudies-arrayexpress
2011-10-10 | E-GEOD-28568 | biostudies-arrayexpress