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MethlyC-Seq of ibm1-4

ABSTRACT: Using MethylC-Seq to provide single-base resulution of DNA methylation status in ibm1-4 mutant 1 sample examined, ibm1-4 mutant

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Jian-Kang Zhu

PROVIDER: E-GEOD-48053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RNA-binding protein regulates plant DNA methylation by controlling mRNA processing at the intronic heterochromatin-containing gene IBM1.

Wang Xingang X Duan Cheng-Guo CG Tang Kai K Wang Bangshing B Zhang Huiming H Lei Mingguang M Lu Kun K Mangrauthia Satendra K SK Wang Pengcheng P Zhu Guohui G Zhao Yang Y Zhu Jian-Kang JK

Proceedings of the National Academy of Sciences of the United States of America 20130903 38

DNA methylation-dependent heterochromatin formation is a conserved mechanism of epigenetic silencing of transposons and other repeat elements in many higher eukaryotes. Genes adjacent to repetitive elements are often also subjected to this epigenetic silencing. Consequently, plants have evolved antisilencing mechanisms such as active DNA demethylation mediated by the REPRESSOR OF SILENCING 1 (ROS1) family of 5-methylcytosine DNA glycosylases to protect these genes from silencing. Some transposon ...[more]

PMID: 24003136

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