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Gene regulation by Pax6 in the lens placode - E9.5

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: David Beebe

PROVIDER: E-GEOD-49230 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The mechanism of lens placode formation: a case of matrix-mediated morphogenesis.

Huang Jie J Rajagopal Ramya R Liu Ying Y Dattilo Lisa K LK Shaham Ohad O Ashery-Padan Ruth R Beebe David C DC

Developmental biology 20110421 1

Although placodes are ubiquitous precursors of tissue invagination, the mechanism of placode formation has not been established and the requirement of placode formation for subsequent invagination has not been tested. Earlier measurements in chicken embryos supported the view that lens placode formation occurs because the extracellular matrix (ECM) between the optic vesicle and the surface ectoderm prevents the prospective lens cells from spreading. Continued cell proliferation within this restr ...[more]

PMID: 21540023

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