Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: David Beebe
PROVIDER: E-GEOD-49216 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nucleic acids research 20130912 22
Lens induction is a classical embryologic model to study cell fate determination. It has been proposed earlier that specific changes in core histone modifications accompany the process of cell fate specification and determination. The lysine acetyltransferases CBP and p300 function as principal enzymes that modify core histones to facilitate specific gene expression. Herein, we performed conditional inactivation of both CBP and p300 in the ectodermal cells that give rise to the lens placode. Ina ...[more]