Dataset Information
Genome-wide measurement of acetylated histone H3 in naïve cells under Treg-inducing conditon
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Takaho Endo
PROVIDER: E-GEOD-49653 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Nature 20131113 7480
Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. However, the molecular mechanisms by which commensal microbes induce colonic Treg cells have been unclear. Here we show that a large bowel microbial fermentation product, butyrate, induce ...[more]
