Unknown,Transcriptomics,Genomics,Proteomics

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Runx3 function in CD8+ splenic T cells

ABSTRACT: CD8+T cells are immune cells that recognize foreign antigens on infected and tumor cells, leading to cytokine-dependent expansion and activation of cytotoxicity towards the targets. To identify Runx3 responsive genes, CD8+ T cells were isolated from spleen of WT and Runx3-/- mice . Six samples (3 WT and 3 Runx3-/-) of freshly isolated CD8+ T cells (resting) were separately obtained from individual mice.

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem 

PROVIDER: E-GEOD-50119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Runx3-mediated transcriptional program in cytotoxic lymphocytes.

Lotem Joseph J   Levanon Ditsa D   Negreanu Varda V   Leshkowitz Dena D   Friedlander Gilgi G   Friedlander Gilgi G   Groner Yoram Y  

PloS one 20131113 11

The transcription factor Runx3 is highly expressed in CD8(+) T and NK cytotoxic lymphocytes and is required for their effective activation and proliferation but molecular insights into the transcription program regulated by Runx3 in these cells are still missing. Using Runx3-ChIP-seq and transcriptome analysis of wild type vs. Runx3(-/-) primary cells we have now identified Runx3-regulated genes in the two cell types at both resting and IL-2-activated states. Runx3-bound genomic regions in both  ...[more]

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