Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of CHD8 binding sites


ABSTRACT: Genome-wide analysis of CHD8 binding sites as well as sites associated with the activating histone marks 2mk4H3 and 3mK4H3. These analyses have been performed by ChIP-chip using a custom microarray containing promoter regions and CpG islands. ChIP experiments were performed with the C33A human cervix carcinoma cell line. ChIP-chip analysis of CHD8, 2mK4H3 and 3mK4H3 in C33A cells

ORGANISM(S): Homo sapiens

SUBMITTER: Jose Reyes 

PROVIDER: E-GEOD-51564 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes.

Subtil-Rodríguez Alicia A   Vázquez-Chávez Elena E   Ceballos-Chávez María M   Rodríguez-Paredes Manuel M   Martín-Subero José I JI   Esteller Manel M   Reyes José C JC  

Nucleic acids research 20131121 4


The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repressive chromatin configuration mediated by the retinoblastoma protein and repressor E2F factors changes at the G1/S transition to allow transcription activation is unclear. Here we show ChIP-on-chip studies that reveal that the chromatin remodeller CHD8 binds ∼ 2000 transcriptionally active promoters. The spectrum of CHD8 target genes was enriched in E2F-dependent genes. We found that CHD8 binds E2F-  ...[more]

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