Genome-wide analysis of CHD8 binding sites
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jose Reyes
PROVIDER: E-GEOD-51564 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes.
Subtil-Rodríguez Alicia A Vázquez-Chávez Elena E Ceballos-Chávez María M Rodríguez-Paredes Manuel M Martín-Subero José I JI Esteller Manel M Reyes José C JC
Nucleic acids research 20131121 4
The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repressive chromatin configuration mediated by the retinoblastoma protein and repressor E2F factors changes at the G1/S transition to allow transcription activation is unclear. Here we show ChIP-on-chip studies that reveal that the chromatin remodeller CHD8 binds ∼ 2000 transcriptionally active promoters. The spectrum of CHD8 target genes was enriched in E2F-dependent genes. We found that CHD8 binds E2F- ...[more]
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