Transcriptomics

Dataset Information

0

Expression data from OT-I CD8 T cells activated with DC in the presence or absence of CpG-Induced Inflammation


ABSTRACT: Inflammatory cytokines promote the accumulation of activated CD8 T cells. Here, we transfer 600 OT-I CD8 T cells iv into naïve C57BL/6 hosts. One day later, 500,000 LPS-matured and OVA257 peptide-coated DC were injected iv into OT-I CD8 T cell seeded hosts with (DC+CpG) or without (DC). Other seeded mice were infected with 2x10^4 virulent Listeria monocytogenes (vLM-OVA) iv. OT-I CD8 T cells were harvested from the spleen, flow sort purified, then RNA was extracted using RNeasy (Qiagen) kit. Naive OT-I CD8 T cells (Naive) were purified from the spleens of OT-I transgenic mice. Each group had three independent biological replicates.Transcriptomes were compared using DAVID analysis (with genes scoring FDR<0.01) and GSEA analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE53200 | GEO | 2013/12/10

SECONDARY ACCESSION(S): PRJNA231091

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-12-10 | E-GEOD-53200 | biostudies-arrayexpress
2010-07-09 | E-GEOD-21360 | biostudies-arrayexpress
2014-07-13 | E-GEOD-58078 | biostudies-arrayexpress
2020-05-08 | GSE146077 | GEO
2017-12-31 | GSE88830 | GEO
2018-03-28 | E-MTAB-6091 | biostudies-arrayexpress
2018-03-01 | GSE110876 | GEO
2020-12-04 | GSE157439 | GEO
2013-09-13 | E-GEOD-26945 | biostudies-arrayexpress
2020-12-22 | GSE130207 | GEO