Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment]

ABSTRACT: To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time. From each of the 25 psoriasis patients, we obtained two pre-dose biopsies, one from a lesion and the other from non-lesional skin in the same general body geography, and two post-dose biopsies. Total RNA was extracted from 6mm punch biopsies that were split in half. A total of 99 samples were run on Affymetrix HU133 Plus 2.0 microarrays. There was no paired non-lesional sample for 'T_lesional_pre-dose' (skn55789).

ORGANISM(S): Homo sapiens

SUBMITTER: Jeannette Bigler 

PROVIDER: E-GEOD-53552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti-IL-17 receptor monoclonal antibody.

Russell Chris B CB   Rand Hugh H   Bigler Jeannette J   Kerkof Keith K   Timour Martin M   Bautista Edgar E   Krueger James G JG   Salinger David H DH   Welcher Andrew A AA   Martin David A DA  

Journal of immunology (Baltimore, Md. : 1950) 20140319 8

The IL-17 pathway is an established driver of psoriasis pathogenesis. We examined the detailed molecular and cellular effects of blockade of IL-17 signaling in human psoriatic skin before and following treatment with brodalumab, a competitive inhibitor of the IL-17 Receptor A subunit. Thousands of aberrantly expressed genes in lesional skin normalized within 2 weeks following brodalumab treatment, with conversion of the lesional psoriasis transcriptome to resemble that seen in nonlesional skin.  ...[more]

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