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Expression data from male and female Schlager hypertensive (BPH/2J) and normotensive (BPN/3J) kidneys

ABSTRACT: Analysis of kidneys from 12 week BPH/2J hypertensive and age matched normotensive BPN/3J controls - males and females. The results provide insights into the genes that are involved in hypertension in both males and females, as well as highlight mechanisms that underlye sex differences in hypertension. We show that female data can be used to refine candidate genes and pathways, as well as highlight potential mechanisms to explain the differences in prevalence and severity of disease between the sexes. Male and female kidneys from 12 week old hypertensive (BPH/2J) and normotensive (BPN/3J) mice were collected for RNA extraction and hybridization on Affymetrix microarrays. We used data obtained from male and female kidneys to identify common genes that are involved in the development of hypertension in males and females

ORGANISM(S): Mus musculus

SUBMITTER: Christine Chiu

PROVIDER: E-GEOD-54015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of genes with altered expression in male and female Schlager hypertensive mice.

Chiu Christine L CL Jackson Kristy L KL Hearn Nerissa L NL Steiner Nicole N Head Geoffrey A GA Lind Joanne M JM

BMC medical genetics 20140830

<h4>Background</h4>Numerous studies have shown sex differences in the onset and severity of hypertension. Despite these sex-differences the majority of animal studies are carried out in males. This study investigated expression changes in both male and female hypertensive mouse kidneys to identify common mechanisms that may be involved in the development of hypertension.<h4>Methods</h4>The Schlager hypertensive mouse model (BPH/2J) and its normotensive control (BPN/3J) were used in this study. R ...[more]

PMID: 25259444

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Expression data from male and female Schlager hypertensive (BPH/2J) and normotensive (BPN/3J) kidneys

Project description:Analysis of kidneys from 12 week BPH/2J hypertensive and age matched normotensive BPN/3J controls - males and females. The results provide insights into the genes that are involved in hypertension in both males and females, as well as highlight mechanisms that underlye sex differences in hypertension. We show that female data can be used to refine candidate genes and pathways, as well as highlight potential mechanisms to explain the differences in prevalence and severity of disease between the sexes.

2014-09-28 | GSE54015 | GEO

Endothelial Transcriptome Remodeling in a Mouse Model of Chronic Hypertension

Project description:Aims: Hypertension poses a significant challenge to vasculature homeostasis and stands as the most common cardiovascular disease in the world. Its effects are especially profound on vasculature-lining endothelial cells that are directly exposed to the effects of excess pressure. Here, we characterize the in vivo transcriptomic response of cardiac endothelial cells to hypertension using the spontaneous hypertension mouse model BPH/2J. Methods and results: Verification of defective endothelial function in the BPH/2J hypertensive mouse strain was followed by acute isolation of cardiac endothelial cells and transcriptional profiling using RNA sequencing. Gene profiles from normotensive BPN/3J mice were compared to hypertensive animals. We observed over 3000 transcriptional differences between groups including pathways consistent with the cardiac fibrosis found in hypertensive animals. Importantly, many of the fibrosis-linked genes also differ between juvenile pre-hypertensive and adult hypertensive BPH/2J mice, suggesting that these transcriptional differences are hypertension-related. We also show that blood pressure normalization with amlodipine resulted in a subset of genes reversing their expression pattern, supporting the hypertension-dependency of altered gene expression. Yet, other transcripts were recalcitrant to therapeutic intervention illuminating the possibility that hypertension may irreversibly alter some endothelial transcriptional patterns. Conclusions: Hypertension has a profound effect on both function and transcription of endothelial cells, the latter of which was only partially restored with normalization of blood pressure. This study represents one of the first to quantify how endothelial cells are reprogrammed at the molecular level in cardiovascular pathology and advances our understanding of the transcriptional events associated with endothelial dysfunction.

2018-04-09 | GSE104530 | GEO

Hypothalamic expression differences between hypertensive BPH/2J and normotensive BPN/3J mouse strains

Project description:Identification of hypothalamic genes whose expression differs between high blood pressure (BPH/2J) and normal blood pressure (BPN/3J) Schlager mouse strains at age 6 weeks (young) and 26 weeks (mature) using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays. The whole hypothalamus was removed from young (6-week-old) and adult (26-week-old) BPH/2J hypertensive mice and age-matched normotensive BPN/2J mice (n=6/group) at peak of 24 h blood pressure. No pooling was performed. After extraction of RNA, cRNA was prepared and arrays performed using Affymetrix GeneChip® Mouse Gene 1.0 ST Arrays at the Ramaciotti Gene Function Analysis facility, University of New South Wales in Sydney, Australia.

2011-04-11 | E-GEOD-25076 | biostudies-arrayexpress

Mus musculus

Project description:Expression data from male and female Schlager hypertensive (BPH/2J) and normotensive (BPN/3J) kidneys

| PRJNA234359 | ENA

Gene expression in the kidneys of two spontaneously hypertensive rat strains at 3 and 6 weeks of age

Project description:We examined gene expression profiles in the rat kidneys using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis of hypertension in the SHR strains, we compared the gene expression levels at 3 and 6 weeks of age, isolated 407 genes showing a more than 4-fold increase or a less than 1/4-fold decrease. The rat kidneys derived from normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP) were　examined. Each strain was run in triplicate.

2015-07-03 | E-GEOD-41453 | biostudies-arrayexpress

Mus musculus

Project description:Hypothalamic expression differences between hypertensive BPH/2J and normotensive BPN/3J mouse strains

| PRJNA134743 | ENA

Transcription profiling of feft ventricle in three genetic rat models of hypertension

Project description:Left ventricle gene expression was analyzed in three models of hypertension in order to clarify the molecular mechanisms associated with left ventricular hypertrophy. Transgenic heterozygous TGR(mRen2)27 rats, overexpressing the mouse renin gene, and their littermate negative controls, spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY), and Lyon hypertensive rats (LH) and their normotensive controls (LL) were included in the study.

2006-08-31 | E-MEXP-357 | biostudies-arrayexpress

Gene expression in the kidneys of two spontaneously hypertensive rat strains at 3 and 6 weeks of age

2015-07-03 | GSE41453 | GEO

Transcription profiling of hypertensive and normotensive rats treated with the AT1 receptor antagonist candesartan and vehicle

Project description:In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment may be of therapeutic advantage. We studied gene expression using Affymetrix Rat Genome U34A arrays from brain microvessels of spontaneously hypertensive rats (SHR) and their normotensive Wistar Kyoto controls (WKY) rats treated with an AT1 antagonist (candesartan, 0.3 mg/kg/day) or vehicle via osmotic minipumps for 4 weeks. Experiment Overall Design: brain microvessels from hypertensive and normotensive rats treated with candesartan and vehicle were analyzed

2007-11-03 | E-GEOD-2739 | biostudies-arrayexpress

Metagenomics assessment of WKY and SHR rodents

Project description:The microbiome plays a significant role in gut brain communication and is linked to several animal and human diseases. Hypertension is characterized by gut dysbiosis, and this study aimed to determine how the gut microbiome differed between male and female normotensive and hypertensive rodents. WKY is a genetic control for spontaneous hypertensive rats or SHR which is well documented to have elevated blood pressure at approximately 8 to 10 weeks. We compared the microbiome of normotensive and hypertensive rodents using a meta-genomics approach.

2023-10-30 | GSE186517 | GEO

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