Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Artemis Hatzigeorgiou
PROVIDER: E-GEOD-55735 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Georgakilas Georgios G Vlachos Ioannis S IS Paraskevopoulou Maria D MD Yang Peter P Zhang Yuhong Y Economides Aris N AN Hatzigeorgiou Artemis G AG
Nature communications 20141210
A large fraction of microRNAs (miRNAs) are derived from intergenic non-coding loci and the identification of their promoters remains 'elusive'. Here, we present microTSS, a machine-learning algorithm that provides highly accurate, single-nucleotide resolution predictions for intergenic miRNA transcription start sites (TSSs). MicroTSS integrates high-resolution RNA-sequencing data with active transcription marks derived from chromatin immunoprecipitation and DNase-sequencing to enable the charact ...[more]