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Next Generation Sequencing of Wild-Type C57BL/6J and FVB/NJ Mouse Cardiac Polyadenylated RNA and Small RNA

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Scot Matkovich

PROVIDER: E-GEOD-55792 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulation of cardiac microRNAs by cardiac microRNAs.

Matkovich Scot J SJ Hu Yuanxin Y Dorn Gerald W GW

Circulation research 20130426 1

<h4>Rationale</h4>MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions. Because microRNAs are products of transcription, the potential exists for microRNAs that regulate transcription to regulate other microRNAs.<h4>Objective</h4>Determine whether cardiac-expressed microRNAs re ...[more]

PMID: 23625950

Publication: 1/2

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