Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Expression profile of ZOS and ZOSM osteosarcoma cell lines


ABSTRACT: Pulmonary metastasis is the main cause of medical failure and death of osteosarcoma patients. Despite intensive search for new therapeutic strategies, survival has not improved during the last two decades. Therefore, it’s very urgent to understand the underlying mechanisms of tumor progression to identify targets of novel therapies for osteosarcoma. We used microarrays to identify the metastasis-driving gene during osteosarcoma metastasis Microarrays are performed in ZOS and ZOSM-two syngenic primary human osteosarcoma cell lines with low and high metastatic potential which are established in our lab

ORGANISM(S): Homo sapiens

SUBMITTER: Jinchang Lu 

PROVIDER: E-GEOD-55957 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.

Lu Jinchang J   Song Guohui G   Tang Qinglian Q   Zou Changye C   Han Feng F   Zhao Zhiqiang Z   Yong Bicheng B   Yin Junqiang J   Xu Huaiyuan H   Xie Xianbiao X   Kang Tiebang T   Lam YingLee Y   Yang Huiling H   Shen Jingnan J   Wang Jin J  

The Journal of clinical investigation 20150330 5


Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic primary human osteosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modifications and expression. Using methylated DNA immunoprecipitation (MeDIP) and microarray  ...[more]

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