Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Development of gene expression signatures for ANP in HUVEC

ABSTRACT: Analysis of HUVEC treated with ANP. ANP is a cardiac hormone, binding to the guanylate cyclase-A (GC-A) receptor with a major role in cardiovascular homeostatic mechanisms. Results provide insight into the molecular mechanisms of ANP in vascular endothelial cell. ANP induced gene expression in HUVEC was measured at 0, 1 and 6 hours. Four independent experiments were performed at each time (0, 1 or 6 hours) for each experiment.

ORGANISM(S): Homo sapiens

SUBMITTER: Takashi Nojiri

PROVIDER: E-GEOD-56976 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.

Nojiri Takashi T Hosoda Hiroshi H Tokudome Takeshi T Miura Koichi K Ishikane Shin S Otani Kentaro K Kishimoto Ichiro I Shintani Yasushi Y Inoue Masayoshi M Kimura Toru T Sawabata Noriyoshi N Minami Masato M Nakagiri Tomoyuki T Funaki Soichiro S Takeuchi Yukiyasu Y Maeda Hajime H Kidoya Hiroyasu H Kiyonari Hiroshi H Shioi Go G Arai Yuji Y Hasegawa Takeshi T Takakura Nobuyuki N Hori Megumi M Ohno Yuko Y Miyazato Mikiya M Mochizuki Naoki N Okumura Meinoshin M Kangawa Kenji K

Proceedings of the National Academy of Sciences of the United States of America 20150316 13

Most patients suffering from cancer die of metastatic disease. Surgical removal of solid tumors is performed as an initial attempt to cure patients; however, surgery is often accompanied with trauma, which can promote early recurrence by provoking detachment of tumor cells into the blood stream or inducing systemic inflammation or both. We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a proph ...[more]

PMID: 25775533

Dataset Information

Development of gene expression signatures for ANP in HUVEC

Publications

Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.

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