Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcriptome data of CD34+ human cord blood-derived cell treated with UM171, SR1 or both


ABSTRACT: mRNA profiling of CD34+ human cord blood-derived cell treated with UM171, SR1 or both mRNA profiles of CD34+ human cord blood-derived cell treated with DMSO (control), SR1 [500nM], UM171 [35nM] or combination SR1 [500nM]+ UM171 [35nM] for 30min, 3hr, 12hr, 24hr, 48hr, 72hr were generated by deep sequencing

ORGANISM(S): Homo sapiens

SUBMITTER: Guy Sauvageau 

PROVIDER: E-GEOD-57299 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon rec  ...[more]

Similar Datasets

2014-10-21 | E-GEOD-57561 | biostudies-arrayexpress
2016-07-20 | E-GEOD-48843 | biostudies-arrayexpress
2016-07-20 | E-GEOD-51984 | biostudies-arrayexpress
2020-12-08 | GSE156900 | GEO
2017-05-02 | E-GEOD-71689 | biostudies-arrayexpress
2014-10-21 | GSE57299 | GEO
2017-05-02 | E-GEOD-71686 | biostudies-arrayexpress
2014-02-05 | E-GEOD-52656 | biostudies-arrayexpress
2017-05-02 | E-GEOD-72061 | biostudies-arrayexpress
2014-07-02 | E-GEOD-52616 | biostudies-arrayexpress