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MicroRNA atlas of dendritic cell (DC) development

ABSTRACT: We determined the microRNA profile of conventional DCs, plasmacytoid DCs, in vitro derived conventional DCs, and DC precursors in the bone marrow. We then compared conventional DCs to plasmacytoid DCs, conventional DCs and in vitro conventional DCs. In addition, we used MDS analysis to compare all the profiles. 14 profiles were produced. Duplicates of LSKs, CMPs, CLPs, CDPs, conventional DCs, plasmacytoid DCs, in vitro cDCs were sequenced.

ORGANISM(S): Mus musculus

SUBMITTER: Mark Chong

PROVIDER: E-GEOD-57442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microRNA expression atlas of mouse dendritic cell development.

Johanson Timothy M TM Cmero Marek M Wettenhall James J Lew Andrew M AM Zhan Yifan Y Chong Mark M W MM

Immunology and cell biology 20141223 5

Dendritic cells (DCs) are sentinel cells of the immune system and are essential for inducing a proper immune response. The mechanisms driving the development of DCs are not fully understood. Although the roles of cytokines and transcription factors have been a major focus, there is now substantial interest in the role of microRNAs (miRNAs). miRNAs are small RNAs that regulate gene expression by targeting messenger RNAs for translational repression and ultimately degradation. By means of deep seq ...[more]

PMID: 25533289

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microRNA atlas of dendritic cell (DC) development

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