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Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Fei Gu

PROVIDER: E-GEOD-57719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.

Lin Zhiqiang Z Zhou Pingzhu P von Gise Alexander A Gu Fei F Ma Qing Q Chen Jinghai J Guo Haidong H van Gorp Pim R R PR Wang Da-Zhi DZ Pu William T WT

Circulation research 20140923 1

<h4>Rationale</h4>Yes-associated protein (YAP), the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEA (transcriptional enhancer activator)-domain sequence-specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the direct transcriptional targets through which YAP exerts its effects are poorly defined.<h4>Objective</h4>To identify direct YA ...[more]

PMID: 25249570

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