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Unknown,Transcriptomics,Genomics,Proteomics

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The identification of RBM47 binding sites and RBM47-dependent alternative splicing events in brain metastatic breast cancer cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Christina Marney

PROVIDER: E-GEOD-58381 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.

Vanharanta Sakari S Marney Christina B CB Shu Weiping W Valiente Manuel M Zou Yilong Y Mele Aldo A Darnell Robert B RB Massagué Joan J

eLife 20140604

The mechanisms through which cancer cells lock in altered transcriptional programs in support of metastasis remain largely unknown. Through integrative analysis of clinical breast cancer gene expression datasets, cell line models of breast cancer progression, and mutation data from cancer genome resequencing studies, we identified RNA binding motif protein 47 (RBM47) as a suppressor of breast cancer progression and metastasis. RBM47 inhibited breast cancer re-initiation and growth in experimenta ...[more]

PMID: 24898756

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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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