Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNAs maintain bivalency in mouse embryonic stem cells [ChIP-seq]


ABSTRACT: The protein Dicer is required for microRNA (miRNA) biogenesis, and therefore Dicer-deficient cells lack all mature, functional miRNAs. Here we investigated the binding of the PRC2 component Ezh2 in wildtype and Dicer-deficient mouse embryonic stem cells genomewide using ChIP-sequencing analysis. Examination of Ezh2 binding in mouse ES cells either proficient (wildtype) or deficient (KO) of the protein Dicer

ORGANISM(S): Mus musculus

SUBMITTER: Gopuraja Dharmalingam 

PROVIDER: E-GEOD-60160 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for transcriptional poising, but the mechanisms that regulate bivalent genes and the bivalent state remain incompletely understood. Examining the contribution of microRNAs (miRNAs) to the regulation of bivalent genes, we found that the miRNA biogenesis enzyme  ...[more]

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