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MicroRNAs maintain bivalency in mouse embryonic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Gopuraja Dharmalingam

PROVIDER: E-GEOD-60161 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNAs of the miR-290-295 Family Maintain Bivalency in Mouse Embryonic Stem Cells.

Graham Bryony B Marcais Antoine A Dharmalingam Gopuraja G Carroll Thomas T Kanellopoulou Chryssa C Graumann Johannes J Nesterova Tatyana B TB Bermange Anna A Brazauskas Pijus P Xella Barbara B Kriaucionis Skirmantas S Higgs Douglas R DR Brockdorff Neil N Mann Matthias M Fisher Amanda G AG Merkenschlager Matthias M

Stem cell reports 20160414 5

Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for transcriptional poising, but the mechanisms that regulate bivalent genes and the bivalent state remain incompletely understood. Examining the contribution of microRNAs (miRNAs) to the regulation of bivalent genes, we found that the miRNA biogenesis enzyme ...[more]

PMID: 27150236

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