Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Knoepfler
PROVIDER: E-GEOD-60207 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yuen Benjamin T K BT Bush Kelly M KM Barrilleaux Bonnie L BL Cotterman Rebecca R Knoepfler Paul S PS
Development (Cambridge, England) 20140819 18
The histone variant H3.3 is involved in diverse biological processes, including development, transcriptional memory and transcriptional reprogramming, as well as diseases, including most notably malignant brain tumors. Recently, we developed a knockout mouse model for the H3f3b gene, one of two genes encoding H3.3. Here, we show that targeted disruption of H3f3b results in a number of phenotypic abnormalities, including a reduction in H3.3 histone levels, leading to male infertility, as well as ...[more]