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Genome-wide mapping of DEK binding in the U937 cell line

ABSTRACT: We find that the DEK oncoprotein preferentially binds close to the transcription start sites of highly and ubiquitously expressed genes. Sequencing of DNA precipitated by an antibofy against the DEK oncoprotein (ChIP-seq).

ORGANISM(S): Homo sapiens

SUBMITTER: Carl Sanden

PROVIDER: E-GEOD-60692 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

Sandén Carl C Järvstråt Linnea L Lennartsson Andreas A Brattås Per Ludvik PL Nilsson Björn B Gullberg Urban U

Molecular cancer 20140912

<h4>Background</h4>The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.<h4>Methods</h4>We performed ChIP-seq analysis in the myeloid cell line U937 and coupled it with epigenetic and gene expression analysis to explore the genome-wide binding pattern of DEK and its role in ...[more]

PMID: 25216995

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Genome-wide mapping of DEK binding in the U937 cell line

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