Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ronald Hart
PROVIDER: E-GEOD-61169 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jiang Dewei D Zhang Ying Y Hart Ronald P RP Chen Jianmin J Herrup Karl K Li Jiali J
Brain : a journal of neurology 20151027 Pt 12
A long-standing mystery surrounding ataxia-telangiectasia is why it is mainly cerebellar neurons, Purkinje cells in particular, that appear vulnerable to ATM deficiency. Here we present data showing that 5-hydroxymethylcytosine (5hmC), a newly recognized epigenetic marker found at high levels in neurons, is substantially reduced in human ataxia-telangiectasia and Atm(-/-) mouse cerebellar Purkinje cells. We further show that TET1, an enzyme that converts 5-methylcytosine (5mC) to 5hmC, responds ...[more]