Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Laura Badi
PROVIDER: E-GEOD-62203 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell reports 20141030 3
Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using human-induced-pluripotent-stem-cell-derived cardiomyocytes. First, we mimic diabetic clinical chemistry to induce a phenotypic surrogate of diabetic cardiomyopathy, observing structural and functional disarray. Next, we consider genetic effects by deriving cardiomyocytes from two diabetic patient ...[more]