Dataset Information
Transcriptional profiling of rat heart ventricular myocytes treated either with PD184352 alone or PD184352 and endothelin-1.
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Angela Clerk
PROVIDER: E-MEXP-2516 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
PloS one 20100402 4
<h4>Background</h4>Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response, but their relative significance in regulating the cardiomyocyte transcriptome is unknown. Our aim was to establish the significance of ERK1/2 and/or RhoA in the early cardiomyocyte transcriptomic response to endothelin-1.<h4>Meth ...[more]
