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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human liver cancers

ABSTRACT: To investigate the mechanisms of liver cancer progression and metastasis, we did expression profiling of human liver cancer and benign tissues. Experiment Overall Design: Total RNA was extracted from human liver cancer at Experiment Overall Design: various stages (T1-1~4, T3-1~6), 2 normal human livers and HuH7 cell line. Genes showed differentially up- or downregulated Experiment Overall Design: by two-fold with respect to the normal human livers Experiment Overall Design: were identified using GeneSpring software version 7.2 (Silicon Experiment Overall Design: Genetics, Agilent Technologies).

ORGANISM(S): Homo sapiens

SUBMITTER: Ann-Ping Tsou

PROVIDER: E-GEOD-6222 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma.

Liao Y-L YL Sun Y-M YM Chau G-Y GY Chau Y-P YP Lai T-C TC Wang J-L JL Horng J-T JT Hsiao M M Tsou A-P AP

Oncogene 20080526 42

A comprehensive microarray analysis of hepatocellular carcinoma (HCC) revealed distinct synexpression patterns during intrahepatic metastasis. Recent evidence has demonstrated that synexpression group member genes are likely to be regulated by master control gene(s). Here we investigate the functions and gene regulation of the transcription factor SOX4 in intrahepatic metastatic HCC. SOX4 is important in tumor metastasis as RNAi knockdown reduces tumor cell migration, invasion, in vivo tumorigen ...[more]

PMID: 18504433

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