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Expression Data from DMSO or SRPIN803 treated ARPE-19 cells

ABSTRACT: We used microarrays to evaluate the effect of SRPIN803 on gene expression in ARPE-19 cells. ARPE-19 cells were treated with SRPIN803 (10 uM) or the negative control (0.1% DMSO) for 4 hours for Total RNA isolation and hybridization on Microarray.

ORGANISM(S): Homo sapiens

SUBMITTER: Masatsugu Denawa

PROVIDER: E-GEOD-62947 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.

Morooka Satoshi S Hoshina Mitsuteru M Kii Isao I Okabe Takayoshi T Kojima Hirotatsu H Inoue Naoko N Okuno Yukiko Y Denawa Masatsugu M Yoshida Suguru S Fukuhara Junichi J Ninomiya Kensuke K Ikura Teikichi T Furuya Toshio T Nagano Tetsuo T Noda Kousuke K Ishida Susumu S Hosoya Takamitsu T Ito Nobutoshi N Yoshimura Nagahisa N Hagiwara Masatoshi M

Molecular pharmacology 20150520 2

Excessive angiogenesis contributes to numerous diseases, including cancer and blinding retinopathy. Antibodies against vascular endothelial growth factor (VEGF) have been approved and are widely used in clinical treatment. Our previous studies using SRPIN340, a small molecule inhibitor of SRPK1 (serine-arginine protein kinase 1), demonstrated that SRPK1 is a potential target for the development of antiangiogenic drugs. In this study, we solved the structure of SRPK1 bound to SRPIN340 by X-ray cr ...[more]

PMID: 25993998

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