Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Cheryl Smith
PROVIDER: E-GEOD-62967 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Spies Noah N Smith Cheryl L CL Rodriguez Jesse M JM Baker Julie C JC Batzoglou Serafim S Sidow Arend A
eLife 20150414
The effects of genetic variation on gene regulation in the developing mammalian embryo remain largely unexplored. To globally quantify these effects, we crossed two divergent mouse strains and asked how genotype of the mother or of the embryo drives gene expression phenotype genomewide. Embryonic expression of 331 genes depends on the genotype of the mother. Embryonic genotype controls allele-specific expression of 1594 genes and a highly overlapping set of cis-expression quantitative trait loci ...[more]