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Analysis of the transcriptional response of Candida parapsilosis following exposure to farnesol

ABSTRACT: We used the results of a genome sequence survey to design and manufacture partial genomic microarrays that were applied to determining the transcriptional response of C. parapsilosis to the presence of exogenous farnesol. Keywords: drug response, farnesol, Transcriptional profiling was performed following exposure to 50 microM of farnesol compare to the control experiment (no treatment). Six independent experiment comparisons (including 3 dye swaps) were performed.

ORGANISM(S): Candida parapsilosis

SUBMITTER: Tristan Rossignol

PROVIDER: E-GEOD-6318 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional response of Candida parapsilosis following exposure to farnesol.

Rossignol Tristan T Logue Mary E ME Reynolds Kieran K Grenon Muriel M Lowndes Noel F NF Butler Geraldine G

Antimicrobial agents and chemotherapy 20070701 7

In Candida albicans, the quorum-sensing molecule farnesol inhibits the transition from yeast to hyphae but has no effect on cellular growth. We show that the addition of exogenous farnesol to cultures of Candida parapsilosis causes the cells to arrest, but not at a specific stage in the cell cycle. The cells are not susceptible to additional farnesol. However, the cells do eventually recover from arrest. Unlike in C. albicans, in C. parapsilosis sterols are localized to the tips of budding cells ...[more]

PMID: 17684006

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