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Maintenance of Leukemic Cell Identity by the Activity of the Polycomb Complex PRC1

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Sri Ganesh Jammula

PROVIDER: E-GEOD-67552 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice.

Rossi Alessandra A Ferrari Karin J KJ Piunti Andrea A Jammula SriGanesh S Chiacchiera Fulvio F Mazzarella Luca L Scelfo Andrea A Pelicci Pier Giuseppe PG Pasini Diego D

Science advances 20161007 10

Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating <i>Hox</i> gene expression (Hox-activating fusions), others impinge on different pathways that do not involve the activation of <i>Hox</i> genes (non-Hox-activating fusions). It has been postulated that one of the main oncogenic properties of the HOXA9 transcription factor i ...[more]

PMID: 27730210

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