Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yulan Piao
PROVIDER: E-GEOD-6952 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cui Chang-Yi CY Hashimoto Tsuyoshi T Grivennikov Sergei I SI Piao Yulan Y Nedospasov Sergei A SA Schlessinger David D
Proceedings of the National Academy of Sciences of the United States of America 20060531 24
Mutations in the EDA gene cause anhidrotic/hypohidrotic ectodermal dysplasia, a disorder characterized by defective formation of hair, sweat glands, and teeth in humans and in a mouse model, "Tabby" (Ta). The gene encodes ectodysplasin, a TNF ligand family member that activates the NF-kappaB-signaling pathway, but downstream targets and the mechanism of skin appendage formation have been only partially analyzed. Comparative transcription profiling of embryonic skin during hair follicle developme ...[more]